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Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (98%), Rat (98%), Chicken (91%), Rhesus Monkey (100%), Bovine (99%), Guinea pig (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: G protein-activated inward rectifier potassium channel 1; GIRK-1; HGIRK1; Inward rectifier K(+) channel Kir3.1; inward rectifier K+ channel KIR3.1; Potassium channel, inwardly rectifying subfamily J member 3; potassium channel, inwardly rectifying subfamily J, member 3; potassium inwardly-rectifying channel subfamily J member 3 splice variant 1e; potassium inwardly-rectifying channel, subfamily J, member 3
基因别名: GIRK-1; GIRK1; Kcnf3; KCNJ3; KGA; KIR3.1
UniProt ID: (Human) P48549, (Mouse) P63250
Entrez Gene ID: (Human) 3760, (Mouse) 16519
分子生物学功能:
ion channel
transporter