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Kir4.1 (KCNJ10) Antibody (PA5-111798) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of Kir4.1 (KCNJ10) in fixed and permeabilized human U-87 MG glioblastoma cell line using Kir4.1 (KCNJ10) Antibody (Product # PA5-111798), (1:100) followed by goat anti-guinea pig-AlexaFluor-488 secondary antibody (green). Cell nuclei were visualized using Hoechst 33342 (blue).
产品信息
PA5-111798
应用
建议稀释比
已发表文章
产品规格
已发表种属
C. elegans
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 356-375 of rat Kir4.1 (Intracellular, C-terminus)
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)KLEESLR EQAEKEGSAL SVR
Homology: Human, mouse amino acid residues are identical.
靶标信息
The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
