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KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: HFTC3; Klotho
基因别名: KL
UniProt ID: (Human) Q9UEF7, (Rat) Q9Z2Y9
Entrez Gene ID: (Human) 9365, (Rat) 83504
分子生物学功能:
glycosidase