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产品信息
MA5-32784
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM93-76
抗原
Synthetic peptide within Human Klotho aa 404-453
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2810060
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HFTC3; Klotho; secreted form of Klotho protein
基因别名: alpha-kl; KL
UniProt ID: (Human) Q9UEF7, (Mouse) O35082
Entrez Gene ID: (Human) 9365, (Mouse) 16591
beta-glucuronidase activity
signal transducer activity
Ras guanyl-nucleotide exchange factor activity
fibroblast growth factor receptor binding
hormone activity
vitamin D binding
beta-glucosidase activity
1-phosphatidylinositol-3-kinase activity
fibroblast growth factor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
hydrolase activity, hydrolyzing O-glycosyl compounds
protein binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
glycosidase
MAPK cascade
carbohydrate metabolic process
energy reserve metabolic process
aging
insulin receptor signaling pathway
fibroblast growth factor receptor signaling pathway
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of bone mineralization
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
calcium ion homeostasis
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
glycosyl compound metabolic process
acute inflammatory response
metabolic process
