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Invitrogen
Ku70/Ku80 Monoclonal Antibody (162)
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Ku70/Ku80 Antibody (MA1-21818) in ICC/IF
Immunofluorescent analysis of Ku70+Ku80 (green) showing staining in the nucleus of A549 cells (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Ku70+Ku80 monoclonal antibody (Product # MA1-21818) in 3% BSA-PBS at... View More
产品信息
MA1-21818
应用
建议稀释比
已发表文章
产品规格
已发表种属
Hamster,
Human,
Mouse,
Non-human primate
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
162
抗原
Human B cell nuclei from plasmacytoid 2p68 cells.
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA1-21818 detects Ku70/Ku80 in human, non-human primate, mouse, rat and xenopus laevis samples. It reacts with a conformational epitope of the p70/p80 dimer, which is destroyed during Western blot. This antibody is not recommended for Western blot procedures and will not cross-react with bovine or rabbit.
靶标信息
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
仅用于科研。不用于诊断过程。未经明确授权不得转售。
