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产品信息
73-079
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N26A/23
抗原
Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (accession number O43526) produced recombinantly in E. Coli.
偶联物
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
靶标信息
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system and KNCQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: KQT like 2; KQT-like 2; KVEBN1; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; Potassium channel subunit alpha KvLQT2; potassium channel, voltage gated KQT-like subfamily Q, member 2; Potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; potassium voltage-gated channel, subfamily Q, member 2; Voltage-gated potassium channel subunit Kv7.2
基因别名: BFNC; EBN; EBN1; ENB1; HNSPC; KCNA11; KCNQ2; KQT2; KV7.2; Nmf134
UniProt ID: (Human) O43526, (Rat) O88943, (Mouse) Q9Z351
Entrez Gene ID: (Human) 3785, (Rat) 170848, (Mouse) 16536
