Proteintech

L-VOCC Polyclonal Antibody

L-VOCC Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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L-VOCC Antibody (21774-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse brain tissue slide using (Product # 21774-1-AP) L-VOCC antibody at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

L-VOCC Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

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产品信息

21774-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:4,000

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免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:400

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

L-VOCC Fusion Protein Ag16455 (1835-2135 aa encoded by BC146846)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.29 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: EVKMNHDTE ACSEPSLLST EMLSYQDDEN RQLTLPEEDK RDIRQSPKRG FLRSASLGRR ASFHLECLKR QKDRGGDISQ KTVLPLHLVH HQALAVAGLS PLLQRSHSPA SFPRPFATPP ATPGSRGWPP QPVPTLRLEG VESSEKLNSS FPSIHCGSWA ETTPGGGGSS AARRVRPVSL MVPSQAGAPG RQFHGSASSL VEAVLISEGL GQFAQDPKFI EVTTQELADA CDMTIEEMES AADNILSGGA PQSPNGALLP FVNCRDAGQD RAGGEEDAGC VRARGRPSEE ELQDSRVYVS SL (1835-2135 aa encoded by B C146846)

靶标信息

CACNA1C encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by CACNA1C binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: brain class C; CACH3; CACN4; CACNA 1D; CACNL1A2; calcium channel voltage-dependent alpha1c subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; calcium channel, voltage-dependent, alpha 1C subunit; calcium channel, voltage-dependent, L type, alpha 1C subunit; DHP receptor; DHPR, alpha-1 subunit; L-type calcium channel alpha-1 subunit; long-NT; LTCC; MBC; MELC-CC; MGC120730; Mouse brain class C; neuronal voltage-gated calcium channel alpha 1C subunit; Rat brain class C; RBC; skeletal muscle-specific calcium channel; voltage-dependent L-type Ca2+ channel alpha 1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-gated calcium channel subunit alpha Cav1.2; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*

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基因别名: CACH2; CACN2; CACNA1C; CACNL1A1; CaV1.2; CCHL1A1; D930026N18Rik; LQT8; MBC; MELC-CC; RATIVS302; TS

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UniProt ID: (Human) Q13936, (Mouse) Q01815, (Rat) P22002

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Entrez Gene ID: (Human) 775, (Mouse) 12288, (Rat) 24239

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