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产品信息
PA5-51792
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643265
产品详细信息
Immunogen sequence: NEDSDQDREE RKLLLDPSSP PTKALNGAEP NYHSLPSART DEQALLSSIL AKTASNIIDV SAADSQGMEQ HEYMDRARQY STRLAVLSSS LTHWKKLPPL PSLTSQPHQV LASEPIPFSD LQQVSRIAAY AYSALSQIRV DAKEELVV
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 97%.
靶标信息
The Ragulator complex is comprised of three proteins, C11orf59, ROBLD3, and MAPKSP1, which targets mTORC1 to lysosomal surfaces. This normal endosomal trafficking is taken advantage of by certain viruses, including coronavirus, which has increased replication when C11orf59 is interfered with. C11orf59 is positively regulated by cellular cholesterol depletion and negatively regulated by cellular cholesterol loading. It is involved in LDL uptake and cholesterol homeostasis. C11orf59 and PPAR-alpha work together to control lipid and carbohydrate metabolism in diabetes. Nearly all effects of C11orf59 are associated with mTORC1 kinase growth promotion, and disregulation of the normal mTOR pathway.
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生物信息学
蛋白别名: Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; Lipid raft adaptor protein p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF Rho; p27RF-Rho; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; RhoA activator C11orf59
基因别名: C11orf59; LAMTOR1; p18; p27RF-Rho; PDRO; PP7157; Ragulator1
UniProt ID: (Human) Q6IAA8
Entrez Gene ID: (Human) 55004
regulation of receptor recycling
endosome organization
lysosome organization
cell cycle arrest
regulation of cholesterol esterification
regulation of cholesterol efflux
cell growth
macroautophagy
positive regulation of TOR signaling
lysosome localization
endosome localization
cellular protein localization
cholesterol homeostasis
positive regulation of MAPK cascade
positive regulation of GTPase activity
regulation of cholesterol import
cellular response to amino acid stimulus
