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LBP Antibody (PA5-79584) in WB
Western blot analysis of LBP in rat thymus extract (lane 1), mouse thymus extract (lane 2), HeLa whole cell lysate (lane 3) and K562 whole cell lysate (lane 4). Sample was incubated with LBP polyclonal antibody (Product # PA5-79584) at a dilution of 0.5 µg/mL. Signal development was performed using a chemiluminescence (ECL) kit.
产品信息
PA5-79584
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human LBP recombinant protein (Position: L177-E446).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746699
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
The LBP protein is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BPI fold containing family D, member 2; LBP; Lipopolysaccharide-binding protein; LPS-binding protein
基因别名: BPIFD2; LBP; Ly88
UniProt ID: (Human) P18428, (Mouse) Q61805
Entrez Gene ID: (Human) 3929, (Mouse) 16803, (Rat) 29469
liver development
leukocyte chemotaxis involved in inflammatory response
macrophage activation involved in immune response
acute-phase response
cellular defense response
opsonization
lipopolysaccharide transport
lipopolysaccharide-mediated signaling pathway
detection of molecule of bacterial origin
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
toll-like receptor 4 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of growth of symbiont in host
innate immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of phagocytosis, engulfment
positive regulation of respiratory burst involved in inflammatory response
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
positive regulation of neutrophil chemotaxis
regulation of membrane permeability
immune system process
transport
lipid transport
defense response to bacterium
