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产品信息
PA5-65879
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2662059
产品详细信息
Immunogen sequence: HYKVSTRSFIN RPNQSRRRED GLPQEGCLWP SDSAAPRLGA SEIMHAPRSR DRFTAPSFIQ RDRFSRFQ
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 81%.
靶标信息
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: clone 22; Low-density lipoprotein receptor class A domain-containing protein 4
基因别名: C18orf1; LDLRAD4
UniProt ID: (Human) O15165
Entrez Gene ID: (Human) 753
negative regulation of epithelial to mesenchymal transition
negative regulation of SMAD protein complex assembly
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of pathway-restricted SMAD protein phosphorylation
