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LGP2 Antibody (PA5-109635) in ICC/IF
Immunofluorescence analysis of LGP2 in U2OS cells. Samples were incubated with LGP2 Polyclonal antibody (Product # PA5-109635) using a dilution of 1:100. Blue: DAPI for nuclear staining.
产品信息
PA5-109635
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 389-678 of human DHX58 (NP_077024.2).
偶联物
Unconjugated
形式
Liquid
浓度
9.77 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2855046
产品详细信息
Immunogen sequence: QQQGLQTVDI RAQLLIGAGN SSQSTHMTQR DQQEVIQKFQ DGTLNLLVAT SVAEEGLDIP HCNVVVRYGL LTNEISMVQA RGRARADQSV YAFVATEGSR ELKRELINEA LETLMEQAVA AVQKMDQAEY QAKIRDLQQA ALTKRAAQAA QRENQRQQFP VEHVQLLCIN CMVAVGHGSD LRKVEGTHHV NVNPNFSNYY NVSRDPVVIN KVFKDWKPGG VISCRNCGEV WGLQMIYKSV KLPVLKVRSM LLETPQGRIQ AKKWSRVPFS VPDFDFLQHC AENLSDLSLD
靶标信息
Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-dependent helicase LGP2; ATP-dependent RNA helicase DHX58; DEXH (Asp-Glu-X-His) box polypeptide 58; ortholog of mouse D11lgp2; probable ATP-dependent helicase LGP2; probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2; Protein D11Lgp2 homolog; RIG-I-like receptor 3; RIG-I-like receptor LGP2; RLR; RLR-3; RNA helicase LGP2
基因别名: B430001I08Rik; D11LGP2; D11LGP2E; DHX58; LGP2; LPG2; RGD1310093; RLR-3
UniProt ID: (Human) Q96C10, (Mouse) Q99J87
Entrez Gene ID: (Human) 79132, (Mouse) 80861, (Rat) 303538
response to virus
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
innate immune response
regulation of innate immune response
negative regulation of innate immune response
defense response to virus
positive regulation of MDA-5 signaling pathway
positive regulation of RIG-I signaling pathway
immune system process
metabolic process
