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LIFR Antibody (PA5-88754) in WB
Western blot was performed using LIFR Polyclonal Antibody (Product # PA5-88754) and a 190 kDa band corresponding to LIFR was observed across all cell lines tested except for SW480 and HCT 116, in which, LIFR promoter methylation has been reported. Non-specific bands (*) were also observed around ~90 kDa and 35 kDa.Whole-cell extracts (40 µg lysate) of HeLa (Lane 1), SiHa (Lane 2), SW480 (Lane 3), RD (Lane 4), and HCT 116 (Lane 5) were electrophoresed using NuPAGE™ 3-8% Tris-Acetate Protein Gel (Product # EA0378BOX), 10 well. Resolved prote... View More
产品信息
PA5-88754
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 500-700 of human LIFR (NP_0023011)
偶联物
形式
Liquid
浓度
1.86 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805105
产品详细信息
Immunogen sequence: NPYTLYTFRI RCSTETFWKW SKWSNKKQHL TTEASPSKGP DTWREWSSDG KNLIIYWKPL PINEANGKIL SYNVSCSSDE ETQSLSEIPD PQHKAEIRLD KNDYIISVVA KNSVGSSPPS KIASMEIPND DLKIEQVVGM GKGILLTWHY DPNMTCDYVI KWCNSSRSEP CLMDWRKVPS NSTETVIESD EFRPGIRYNF F; Positive Samples: Mouse skeletal muscle; Cellular Location: Cell membrane, Single-pass type I membrane protein
靶标信息
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD118; D-factor/LIF receptor; FLJ98106; FLJ99923; Leukemia inhibitory factor receptor; leukemia inhibitory factor receptor alpha chain; LIF R beta; LIF receptor; LIF-R; soluble differentiation-stimulating factor receptor
基因别名: A230075M04Rik; AW061234; LIF; Lifr
UniProt ID: (Mouse) P42703
Entrez Gene ID: (Mouse) 16880
cytokine receptor activity
ciliary neurotrophic factor receptor activity
leukemia inhibitory factor receptor activity
oncostatin-M receptor activity
ciliary neurotrophic factor receptor binding
protein binding
growth factor binding
cytokine binding
protein heterodimerization activity
transmembrane signal receptor
positive regulation of cell proliferation
negative regulation of muscle cell apoptotic process
cytokine-mediated signaling pathway
organ regeneration
response to cytokine
oncostatin-M-mediated signaling pathway
neuron projection morphogenesis
leukemia inhibitory factor signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
