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LILRB2 Antibody (PA5-88383) in ICC/IF
Immunofluorescence analysis of Leukocyte immunoglobulin-like receptor subfamily B member 2 was performed using 70% confluent log phase THP-1 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with LILRB2 Polyclonal Antibody (Product # PA5-88383) at 5 µg/mL in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary A... View More
产品信息
PA5-88383
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 479-598 of human LILRB2/CD85d/ILT4 (NP_0058653)
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804871
产品详细信息
Immunogen sequence: LFLILRHRRQ GKHWTSTQRK ADFQHPAGAV GPEPTDRGLQ WRSSPAADAQ EENLYAAVKD TQPEDGVEMD TRAAASEAPQ DVTYAQLHSL TLRRKATEPP PSQEREPPAE PSIYATLAIH; Positive Samples: THP-1, U-87MG; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
LILRB2 (ILT4) gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD85 antigen-like family member D; CD85d; CD85d antigen; Ig-like transcript 4; ILT-4; Immunoglobulin-like transcript 4; leucocyte Ig-like receptor B2; Leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LIR-2; LIR2CD85D; MIR-10; MIR10LILRA6; Monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10
基因别名: CD85D; ILT-4; ILT4; LILRB2; LIR-2; LIR2; MIR-10; MIR10
UniProt ID: (Human) Q8N423
Entrez Gene ID: (Human) 10288
adaptive immune response
negative regulation of antigen processing and presentation
positive regulation of tolerance induction
positive regulation of T cell tolerance induction
immune response-inhibiting cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
immune response
cellular defense response
signal transduction
cell surface receptor signaling pathway
cell-cell signaling
positive regulation of interleukin-6 production
heterotypic cell-cell adhesion
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of regulatory T cell differentiation
regulation of immune response
negative regulation of immune response
negative regulation of calcium ion transport
cellular response to lipopolysaccharide
regulation of dendritic cell differentiation
