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产品信息
PA5-30240
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein fragment corresponding to a region within amino acids 1 and 216 of Human LIMS1
偶联物
形式
Liquid
浓度
0.88 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2547714
产品详细信息
Recommended positive controls: A549, HeLa, HCT116.
Predicted reactivity: Human (99%), Mouse (99%), Rat (99%), Zebrafish (95%), Xenopus laevis (97%), Pig (98%), Chicken (95%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LIM and senescent cell antigen-like domains 1; LIM and senescent cell antigen-like-containing domain protein 1; LIM-type zinc finger domains 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48; senescent cell antigen
基因别名: LIMS1; PINCH; PINCH-1; PINCH1
UniProt ID: (Human) P48059
Entrez Gene ID: (Human) 3987
epithelial to mesenchymal transition
cell aging
positive regulation of gene expression
positive regulation of cell-substrate adhesion
cell junction assembly
positive regulation of GTPase activity
establishment of protein localization
negative regulation of transcription, DNA-templated
regulation of epithelial cell proliferation
positive regulation of focal adhesion assembly
cellular response to transforming growth factor beta stimulus
positive regulation of substrate adhesion-dependent cell spreading
