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产品信息
H00009361-D01P
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
LONP1 (NP_004784.2, 1 a.a. approximately 959 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MAASTGYVRL WGAARCWVLR RPMLAAAGGR VPTAAGAWLL RGQRTCDASP PWALWGRGPA IGGQWRGFWE ASSRGGGAFS GGEDASEGGA EEGAGGAGGS AGAGEGPVIT ALTPMTIPDV FPHLPLIAIT RNPVFPRFIK IIEVKNKKLV ELLRRKVRLA QPYVGVFLKR DDSNESDVVE SLDEIYHTGT FAQIHEMQDL GDKLRMIVMG HRRVHISRQL EVEPEEPEAE NKHKPRRKSK RGKKEAEDEL SARHPAELAM EPTPELPAEV LMVEVENVVH EDFQVTEEVK ALTAEIVKTI RDIIALNPLY RESVLQMMQA GQRVVDNPIY LSDMGAALTG AESHELQDVL EETNIPKRLY KALSLLKKEF ELSKLQQRLG REVEEKIKQT HRKYLLQEQL KIIKKELGLE KDDKDAIEEK FRERLKELVV PKHVMDVVDE ELSKLGLLDN HSSEFNVTRN YLDWLTSIPW GKYSNENLDL ARAQAVLEED HYGMEDVKKR ILEFIAVSQL RGSTQGKILC FYGPPGVGKT SIARSIARAL NREYFRFSVG GMTDVAEIKG HRRTYVGAMP GKIIQCLKKT KTENPLILID EVDKIGRGYQ GDPSSALLEL LDPEQNANFL DHYLDVPVDL SKVLFICTAN VTDTIPEPLR DRMEMINVSG YVAQEKLAIA ERYLVPQARA LCGLDESKAK LSSDVLTLLI KQYCRESGVR NLQKQVEKVL RKSAYKIVSG EAESVEVTPE NLQDFVGKPV FTVERMYDVT PPGVVMGLAW TAMGGSTLFV ETSLRRPQDK DAKGDKDGSL EVTGQLGEVM KESARIAYTF ARAFLMQHAP ANDYLVTSHI HLHVPEGATP KDGPSAGCTI VTALLSLAMG RPVRQNLAMT GEVSLTGKIL PVGGIKEKTI AAKRAGVTCI VLPAENKKDF YDLAAFITEG LEVHFVEHYR EIFDIAFPDE QAEALAVER
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; Lon protease-like protein; LONHs; LONP; LONP1; Mitochondrial ATP-dependent protease Lon; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15
基因别名: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776, (Mouse) Q8CGK3
Entrez Gene ID: (Human) 9361, (Mouse) 74142
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
ADP binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
nucleotide binding
DNA binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
serine protease
mitochondrial genome maintenance
response to hypoxia
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
aging
response to hormone
response to aluminum ion
mitochondrial DNA metabolic process
cellular response to oxidative stress
chaperone-mediated protein complex assembly
protein homooligomerization
proteolysis involved in cellular protein catabolic process
oxidation-dependent protein catabolic process
regulation of mitochondrial DNA replication
proteolysis
protein catabolic process
cellular protein complex assembly
