Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
LONP1 Polyclonal Antibody
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
产品信息
PA5-51692
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.30 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2643424
产品详细信息
Immunogen sequence: VEEKIKQTHR KYLLQEQLKI IKKELGLEKD DKDAIEEKFR ERLKELVVPK HVMDVVDEEL SKLGLLDNHS SEFNVTRNYL DWLTSIPWGK YSNENLDLAR AQAVLEEDHY GMEDVKKRIL EFIAVSQLRG STQGKILCFY GP
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
靶标信息
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia. Alternatively spliced transcript variants have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: h LonHS; hLON ATP-dependent protease; Lon protease homolog, mitochondrial; lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}; Lon protease-like protein; lon protease-like protein {ECO:0000255|HAMAP-Rule:MF_03120}; LONHs; LONP; LONP {ECO:0000255|HAMAP-Rule:MF_03120}; LONP1; Mitochondrial ATP-dependent protease Lon; mitochondrial ATP-dependent protease Lon {ECO:0000255|HAMAP-Rule:MF_03120}; mitochondrial lon protease-like protein; protease, serine, 15; Serine protease 15; serine protease 15 {ECO:0000255|HAMAP-Rule:MF_03120}
基因别名: 1200017E13Rik; CODASS; hLON; LON; LonHS; LONP; LONP1; PIM1; PRSS15
UniProt ID: (Human) P36776, (Mouse) Q8CGK3, (Rat) Q924S5
Entrez Gene ID: (Human) 9361, (Mouse) 74142, (Rat) 170916
single-stranded DNA binding
single-stranded RNA binding
ATP-dependent peptidase activity
serine-type endopeptidase activity
protein binding
ATP binding
ADP binding
sequence-specific DNA binding
G-quadruplex DNA binding
DNA polymerase binding
mitochondrial light strand promoter anti-sense binding
mitochondrial heavy strand promoter anti-sense binding
mitochondrial light strand promoter sense binding
mitochondrial heavy strand promoter sense binding
nucleotide binding
DNA binding
peptidase activity
serine-type peptidase activity
hydrolase activity
ATPase activity
serine protease
mitochondrial genome maintenance
response to hypoxia
misfolded or incompletely synthesized protein catabolic process
mitochondrion organization
aging
response to hormone
response to aluminum ion
mitochondrial DNA metabolic process
cellular response to oxidative stress
chaperone-mediated protein complex assembly
protein homooligomerization
proteolysis involved in cellular protein catabolic process
oxidation-dependent protein catabolic process
regulation of mitochondrial DNA replication
proteolysis
protein catabolic process
cellular protein complex assembly
