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产品信息
PA5-70035
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide corresponding to a region of mouse LOXL2 (aa 607-656).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2690418
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 83%
靶标信息
This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
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生物信息学
蛋白别名: Lysyl oxidase homolog 2; Lysyl oxidase-like protein 2
基因别名: 1110004B06Rik; 4930526G11Rik; 9430067E15Rik; Loxl2
UniProt ID: (Mouse) P58022
Entrez Gene ID: (Mouse) 94352
chromatin binding
transcription corepressor activity
protein-lysine 6-oxidase activity
scavenger receptor activity
copper ion binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
methylated histone binding
metal ion binding
oligosaccharide binding
oxidase
response to hypoxia
epithelial to mesenchymal transition
endothelial cell proliferation
sprouting angiogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular protein modification process
chromatin modification
histone modification
protein deamination
collagen fibril organization
positive regulation of chondrocyte differentiation
endothelial cell migration
negative regulation of transcription, DNA-templated
response to copper ion
oxidation-reduction process
