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产品信息
BS-2880R
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human EDG2/LPAR1, amino acids 281-364.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; G-protein coupled receptor 26; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor 1; Lysophosphatidic acid receptor Edg-2; Rec1.3; ventricular zone gene 1; VZG-1
基因别名: AI326300; edg-2; EDG2; Gpcr26; Gpcr91; GPR26; Kdt2; LPA1; LPAR1; Mrec1.3; rec.1.3; vzg-1; VZG1
UniProt ID: (Human) Q92633, (Rat) P61794, (Mouse) P61793
Entrez Gene ID: (Human) 1902, (Rat) 116744, (Mouse) 14745
activation of MAPK activity
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
regulation of cell shape
negative regulation of neuron projection development
oligodendrocyte development
cerebellum development
optic nerve development
corpus callosum development
negative regulation of cAMP biosynthetic process
bleb assembly
positive regulation of Rho protein signal transduction
myelination
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
positive regulation of stress fiber assembly
cell chemotaxis
positive regulation of dendritic spine development
cellular response to oxygen levels
positive regulation of smooth muscle cell chemotaxis
cellular response to 1-oleoyl-sn-glycerol 3-phosphate
positive regulation of cell death
neurogenesis
signal transduction
