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Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: LPHN1.
Adgrl1 (Latrophilin-1) is a calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Adgrl1 is a receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization, and may be implicated in the regulation of exocytosis. The Adgrl1 gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Adgrl1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms of Adgrl1. Diseases associated with ADGRL1 include Dermatophytosis and Retinal Degeneration, Late-Onset, Autosomal Dominant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Adhesion G protein-coupled receptor L1; Calcium-independent alpha-latrotoxin receptor 1; CIRL-1; latrophilin 1; Latrophilin-1; Lectomedin-2; Lphh2
基因别名: 2900070I05Rik; ADGRL1; AI182398; Cirl; CIRL1; CL1; CL1BA; CLIBA; KIAA0821; LEC2; LPHN1; mKIAA0821
UniProt ID: (Human) O94910, (Mouse) Q80TR1, (Rat) O88917
Entrez Gene ID: (Human) 22859, (Mouse) 330814, (Rat) 65096
分子生物学功能:
G-protein coupled receptor