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LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: crooked; low density lipoprotein receptor-related protein 5; low density lipoprotein receptor-related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein receptor-related protein 7; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 5; Low-density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 7; LRP-5; LRP-6; LRP-7
基因别名:
ADCAD2; BMND1; C030016K15Rik; Cd; EVR1; EVR4; Gw; HBM; LR3; LRP-5; LRP5; LRP6; LRP7; mKIAA4142; OPPG; OPS; OPTA1; ska26; ska
UniProt ID: (Human) O75197, (Human) O75581, (Mouse) Q91VN0, (Mouse) O88572
Entrez Gene ID: (Human) 4041, (Human) 4040, (Rat) 293649, (Mouse) 16973, (Rat) 312781, (Mouse) 16974