Invitrogen

LRP6 Monoclonal Antibody (290913)

查看其他21个LRP6抗体

产品信息

MA5-23995

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

-

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2B

分类

Monoclonal

类型

Antibody

克隆号

290913

抗原

CHO-derived recombinant mouse LRP-6 Met1-Pro1368

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2609984

产品详细信息

In direct ELISAs, this antibody shows approximately 50-60% cross-reactivity with recombinant human (rh) LRP-6 and no cross-reactivity with rhLDL R.

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: crooked; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6

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基因别名: C030016K15Rik; Cd; Gw; Lrp6; ska26; ska; skax26

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UniProt ID: (Mouse) O88572

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Entrez Gene ID: (Mouse) 16974

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low-density lipoprotein receptor activity receptor binding frizzled binding protein binding Wnt-protein binding kinase inhibitor activity toxin transporter activity apolipoprotein binding identical protein binding protein homodimerization activity Wnt-activated receptor activity coreceptor activity involved in Wnt signaling pathway apolipoprotein

参与通路

gastrulation with mouth forming second somitogenesis neural tube closure negative regulation of protein phosphorylation heart looping morphogenesis of an epithelium positive regulation of mesenchymal cell proliferation pericardium morphogenesis axis elongation regulation of transcription, DNA-templated negative regulation of protein kinase activity endocytosis receptor-mediated endocytosis positive regulation of cytosolic calcium ion concentration chemical synaptic transmission multicellular organism development embryonic pattern specification dorsal/ventral axis specification anterior/posterior pattern specification neural crest formation neural crest cell differentiation Wnt signaling pathway single organismal cell-cell adhesion cerebellum morphogenesis thalamus development cerebral cortex cell migration forebrain radial glial cell differentiation forebrain generation of neurons Wnt signaling pathway involved in forebrain neuroblast division neural tube development formation of radial glial scaffolds cerebral cortex development negative regulation of Wnt signaling pathway embryonic limb morphogenesis forebrain development midbrain development midbrain-hindbrain boundary development negative regulation of smooth muscle cell apoptotic process limb morphogenesis embryonic forelimb morphogenesis embryonic hindlimb morphogenesis external genitalia morphogenesis post-anal tail morphogenesis cell migration involved in gastrulation regulation of cell proliferation odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of apoptotic process Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of fat cell differentiation positive regulation of ossification positive regulation of bone resorption positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter bone remodeling embryonic camera-type eye morphogenesis generation of neurons skeletal system morphogenesis negative regulation of epithelial cell proliferation positive regulation of sequence-specific DNA binding transcription factor activity response to folic acid palate development convergent extension retina morphogenesis in camera-type eye embryonic retina morphogenesis in camera-type eye canonical Wnt signaling pathway regulation of cell development face morphogenesis bone morphogenesis branching involved in mammary gland duct morphogenesis trachea cartilage morphogenesis mammary placode formation mammary gland duct morphogenesis canonical Wnt signaling pathway involved in cardiac neural crest cell differentiation involved in heart development canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation cellular response to cholesterol dopaminergic neuron differentiation negative regulation of protein serine/threonine kinase activity primitive streak formation receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport Wnt signaling pathway involved in somitogenesis axis elongation involved in somitogenesis positive regulation of canonical Wnt signaling pathway toxin transport negative regulation of non-canonical Wnt signaling pathway positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis negative regulation of planar cell polarity pathway involved in pericardium morphogenesis negative regulation of planar cell polarity pathway involved in neural tube closure