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产品信息
CF805611
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
OTI5H9
抗原
Human recombinant protein fragment corresponding to amino acids 182-422 of human LRRTM1 produced in E.coli.
偶联物
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM1 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia.
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生物信息学
蛋白别名: leucine-rich repeat transmembrane neuronal 1 protein; Leucine-rich repeat transmembrane neuronal protein 1
基因别名: LRRTM1; UNQ675/PRO1309
UniProt ID: (Human) D6W5K1
Entrez Gene ID: (Human) 347730
negative regulation of receptor internalization
negative regulation of protein kinase activity
locomotory behavior
biological_process
cytokine-mediated signaling pathway
protein localization to synapse
exploration behavior
negative regulation of JAK-STAT cascade
synapse organization
positive regulation of synapse assembly
long-term synaptic potentiation
