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LUM Antibody (MA5-35135) in IHC (P)
Immunohistochemistry analysis of LUM in paraffin-embedded mouse kidney. Samples were incubated with LUM Monoclonal antibody (Product # MA5-35135) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
MA5-35135
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC0637
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 212-338 of human Lumican (LUM) (NP_0023361)
偶联物
形式
Liquid
浓度
1.25 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849040
产品详细信息
Immunogen sequence: LDNNKISNIP DEYFKRFNAL QYLRLSHNEL ADSGIPGNSF NVSSLVELDL SYNKLKNIPT VNENLENYYL EVNQLEKFDI KSFCKILGPL SYSKIKHLRL DGNRISETSL PPDMYECLRV ANEVTLN
靶标信息
LUM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, this protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. The protein is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Keratan sulfate proteoglycan lumican; KSPG lumican; Lumican; Lumican precursor; lumican proteoglycan
基因别名: Lcn; LDC; LUM; SLRR2D
UniProt ID: (Human) P51884, (Mouse) P51885
Entrez Gene ID: (Human) 4060, (Mouse) 17022
visual perception
collagen fibril organization
positive regulation of transcription from RNA polymerase II promoter
axonogenesis
response to organic cyclic compound
keratan sulfate biosynthetic process
extracellular matrix organization
positive regulation of transforming growth factor beta1 production
keratan sulfate catabolic process
cartilage development
response to growth factor
