Invitrogen

Lamin B2 Monoclonal Antibody (D5-C2)

Lamin B2 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

Lamin B2 Antibody (MA5-44617) in ICC/IF

Immunocytochemistry analysis of LMNB2 in PC-3M cells (red). Samples were incubated in LMNB2 Monoclonal antibody (Product # MA5-44617). Cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS.

Product Image Gallery

产品信息

MA5-44617

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:2,000

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫细胞化学 (ICC/IF)

1:200-1:500

产品规格

种属反应

Human, Mouse, Rat, Zebrafish

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

D5-C2

抗原

Synthetic peptide within Human LMNB2 aa 571-620/620.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.2% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2931077

靶标信息

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。