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LexA DNA-binding Domain Antibody (39184) in WB
LexA DNA-binding Domain pAb tested by Western blot. 20 µg of crude yeast protein extracts probed with LexA DNA-binding Domain pAb (1:100,000 dilution). Lane 1: Extract from wild-type yeast. Lane 2: Extract from yeast expressing a LexA-Retinoblastoma (Rb) fusion protein.
产品信息
39184
应用
建议稀释比
已发表文章
产品规格
种属反应
Yeast
已发表种属
Yeast
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This LexA DNA-binding Domain antibody was raised against recombinant protein corresponding to full-length E. coli LexA.
偶联物
Unconjugated
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum with 30% glycerol
内含物
0.035% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2793174
靶标信息
E. coli LexA protein inhibits the transcription of the genes belonging to the SOS regulon that are related to DNA repair and cell division by recognizing and binding to the SOS-box sequence. LexA‘s self-protease activity is promoted by RecA protein which, responding to DNA damage, is activated by its binding to single-strand DNA accumulated in the cells. It is cleaved into two fragments and loses its function as a repressor. As the result, the expression of genes belonging to the SOS regulon is induced, and mutagenic activity in the cells are enhanced.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
