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The Zyxin family of proteins contains five members: Ajuba, Limd1, LPP, TRIP6 and Zyxin. Limd1 (LIM domain-containing protein 1) is a ubiquitously expressed tumor suppressor containing three LIM zinc-binding domains. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. Limd1 interacts with the proteins SQSTM1, Rb, p62 and TRAF6. Limd1 was first identified when the deletion of its gene was noted in some cervical cancers. Limd1 blocks in vitro and in vivo tumor growth and is downregulated in lung cancer.
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蛋白别名: LIM domain-containing protein 1
基因别名: AW822033; D9Ertd192e; LIMD1
UniProt ID: (Human) Q9UGP4, (Mouse) Q9QXD8, (Rat) B5DEH0
Entrez Gene ID: (Human) 8994, (Mouse) 29806, (Rat) 316101
分子生物学功能:
transcription cofactor