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LUM is a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, this protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. The protein is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Keratan sulfate proteoglycan lumican; KSPG lumican; Lumican; Lumican precursor; lumican proteoglycan
基因别名: Lcn; LDC; LUM; SLRR2D
UniProt ID: (Human) P51884, (Rat) P51886, (Mouse) P51885
Entrez Gene ID: (Human) 4060, (Rat) 81682, (Mouse) 17022