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Cadherins are a multigene family of Ca++-dependent cell adhesion molecules. They are transmembrane glycoproteins consisting of an extracellular domain, which mediates Ca++-dependent intercellular adhesion by homophilic interactions, a transmembrane region and a cytoplasmic domain. The extracellular domain is divided into a series of subdomains designated EC1-EC5. Homolgies between different members of the cadherin family are most prominent in the cytoplasmic domain and in EC1 and EC2 and much less so in EC5 of the extracellular domain and in the transmembrane region. The binding properties and specificities of the adhesive function are located in the N-terminal part of the molecules. Four members of the cadherin family have been identified and molecularly cloned from mammalian cells. These include the neuronal (N), epithelial (E), placental (P) and muscle (M) cadherins. M-cadherin is not found in fibroblasts but is expressed at low level in myoblasts and is upregulated following induction of myotube formation, suggesting a specific function in skeletal muscle cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cadherin 15, type 1, M-cadherin (myotubule); Cadherin-14; Cadherin-15; cadherin-3; HAR; M cadherin; M-cadherin; Muscle cadherin; muscle-cadherin; XLKD1
基因别名: AI323380; CDH14; CDH15; CDH3; CDHM; MCAD; MRD3
UniProt ID: (Human) P55291, (Mouse) P33146
Entrez Gene ID: (Human) 1013, (Rat) 361432, (Mouse) 12555