Proteintech

MAF Polyclonal Antibody

MAF Antibody in Immunocytochemistry (ICC/IF)

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MAF Antibody (55013-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed A431 cells using 55013-1-AP (MAF antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MAF Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MAF Antibody in Immunoprecipitation (IP)

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产品信息

55013-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:50-1:500

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免疫沉淀 (IP)

0.5-4.0 µg

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不适用 (N/A)

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.35 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

The antibody is specific to MAF.

靶标信息

c-maf is the cellular counterpart of oncogenic v-maf that belongs to the family of basic region leucine zipper domain transcription factors. The leucine-zipper domain is involved in the interaction with LRPICD. There are two forms of human c-maf mRNA, c-maf-long and c-maf-short. It is identified in the genome of the acute transforming avian retrovirus AS42. c-maf targets are IL-4 in Th2 cells, the crystalline genes in lens fiber cells, insulin gene in islet, p53 and L7 where it exerts its transcriptional role through binding to a Maf recognition element (MARE). It regulates Th2 differentiation and lineage-specific hematopoiesis. c-maf is a transcription factor for IL-10 gene expression in LPS-activated macrophages. Chromosomal aberration involving maf is found in some forms of multiple myeloma. It is expressed in myeloma cell lines and resting monocytes/macrophages.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Molecular Mechanisms Driving IL-10- Producing B Cells Functions: STAT3 and c-MAF as Underestimated Central Key Regulators?

Frontiers in immunology

Michée-Cospolite M,Boudigou M,Grasseau A,Simon Q,Mignen O,Pers JO,Cornec D,Le Pottier L,Hillion S

Fri Apr 08 00:00:00 EDT 2022

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Journal of immunology (Baltimore, Md. : 1950)

Fan TW,Daneshmandi S,Cassel TA,Uddin MB,Sledziona J,Thompson PT,Lin P,Higashi RM,Lane AN

Tue Nov 01 00:00:00 EDT 2022

Deletion of Cdk5 in Macrophages Ameliorates Anti-Inflammatory Response during Endotoxemia through Induction of C-Maf and Il-10.

International journal of molecular sciences

Pfänder P,Eiers AK,Burret U,Vettorazzi S

Mon Sep 06 00:00:00 EDT 2021

Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis.

Cell communication and signaling : CCS

Sun T,Xu Y,Xu Z,Cao B,Zhang Z,Wang Q,Kong Y,Mao X

Wed Feb 24 00:00:00 EST 2021

Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells.

Journal of immunology (Baltimore, Md. : 1950)

Hewitson JP,West KA,James KR,Rani GF,Dey N,Romano A,Brown N,Teichmann SA,Kaye PM,Lagos D

Mon Jun 01 00:00:00 EDT 2020

The novel mutation P36R in LRP5L contributes to congenital membranous cataract via inhibition of laminin γ1 and c-MAF.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

Sun L,Song F,Liu H,Wang C,Tang X,Li Z,Ge H,Liu P

Tue Dec 01 00:00:00 EST 2020

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.

The Journal of biological chemistry

He Y,Wang S,Tong J,Jiang S,Yang Y,Zhang Z,Xu Y,Zeng Y,Cao B,Moran MF,Mao X

Fri Feb 14 00:00:00 EST 2020

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.

Cell death & disease

Xu Y,Sun T,Zeng K,Xu M,Chen J,Xu X,Zhang Z,Cao B,Tang X,Wu D,Kong Y,Zeng Y,Mao X

Wed Sep 30 00:00:00 EDT 2020

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf.

Cell death & disease

Xu Y,Sun T,Zeng K,Xu M,Chen J,Xu X,Zhang Z,Cao B,Tang X,Wu D,Kong Y,Zeng Y,Mao X

Wed Sep 30 00:00:00 EDT 2020

Mebendazole elicits potent antimyeloma activity by inhibiting the USP5/c-Maf axis.

Acta pharmacologica Sinica

Chen XH,Xu YJ,Wang XG,Lin P,Cao BY,Zeng YY,Wang Q,Zhang ZB,Mao XL,Zhang T

Sun Dec 01 00:00:00 EST 2019

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.

Immunity

Wu B,Zhang S,Guo Z,Wang G,Zhang G,Xie L,Lou J,Chen X,Wu D,Bergmeier W,Zheng J,Wan YY

Tue Nov 20 00:00:00 EST 2018

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs.

Immunity

Wu B,Zhang S,Guo Z,Wang G,Zhang G,Xie L,Lou J,Chen X,Wu D,Bergmeier W,Zheng J,Wan YY

Tue Nov 20 00:00:00 EST 2018

生物信息学

蛋白别名: Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; C-Maf; c-Maf long form; c-maf proto-oncogene; MGC71685; Proto-oncogene c-Maf; T lymphocyte c-maf long form; Transcription factor Maf; Transcription factor Maf-2; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog

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基因别名: 2810401A20Rik; A230108G15Rik; AW047063; AYGRP; c-MAF; CCA4; cMaf; CTRCT21; MAF; Maf2

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UniProt ID: (Human) O75444, (Rat) P54844, (Mouse) P54843

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Entrez Gene ID: (Human) 4094, (Rat) 54267, (Mouse) 17132

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功能

transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding protein binding sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein homodimerization activity protein heterodimerization activity basic leucine zipper transcription factor

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