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MAG Antibody (MA5-52084) in IHC (P)
Immunohistochemical analysis of MAG was performed using formalin-fixed paraffin-embedded mouse brain and liver tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58 diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes... View More
产品信息
MA5-52084
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH02-42
抗原
Recombinant protein within human mag aa 1- 536.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_3099398
产品详细信息
Tissue Specificity: central and peripheral nervous system
Positive Control: Mouse brain (no heat) tissue lysate, mouse cerebellum tissue lysate, rat brain (no heat) tissue lysate, rat cerebellum tissue lysate, human cerebellum tissue, mouse brain tissue, mouse cerebellum tissue, mouse hippocampus tissue, rat brain tissue, rat cerebellum tissue, rat hippocampus tissue.
Subcellular Location: Cell membrane.
Predicted band size: 69 kDa.
靶标信息
The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 1B236; Brain neuron cytoplasmic protein 3; Myelin-associated glycoprotein; S-MAG (C-term.); sialic acid binding Ig-like lectin 4A; Sialic acid-binding Ig-like lectin 4a; sialic acid-binding immunoglobulin-like lectin 4A; Siglec-4a
基因别名: GMA; MAG; S-MAG; SIGLEC-4A; SIGLEC4A; SPG75
UniProt ID: (Human) P20916, (Rat) P07722, (Mouse) P20917
Entrez Gene ID: (Human) 4099, (Rat) 29409, (Mouse) 17136
cell adhesion
positive regulation of myelination
positive regulation of astrocyte differentiation
negative regulation of axonogenesis
leukocyte migration
cellular response to mechanical stimulus
nervous system development
negative regulation of neuron projection development
substantia nigra development
negative regulation of neuron differentiation
