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产品信息
H00004216-M08
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
4F10
抗原
MAP3K4 (NP_005913, 1201 a.a. approximately 1300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH SSPTEERDEP AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS
靶标信息
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); JNKK1; MAP three kinase 1; MAP/ERK kinase kinase 4; MAP2K4; MAPK/ERK kinase kinase 4; MEK kinase 4; mitogen activated protein kinase kinase kinase 4; Mitogen-activated protein kinase kinase kinase 4; predicted protein of HQ0412; PRKMK4; SERK1; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of; T-associated sex reversal
基因别名: D17Rp17; D17Rp17e; KIAA0213; MAP3K4; MAPKKK4; Mek4b; MEKK 4; MEKK4; mKIAA0213; MTK1; PRO0412; RP17; Rp17a; Tas
UniProt ID: (Human) Q9Y6R4, (Mouse) O08648
Entrez Gene ID: (Human) 4216, (Mouse) 26407
MAP kinase kinase kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPKK activity
placenta development
response to UV-C
regulation of gene expression
male germ-line sex determination
positive regulation of telomere maintenance via telomerase
intracellular signal transduction
positive regulation of JUN kinase activity
positive regulation of telomerase activity
chorionic trophoblast cell differentiation
positive regulation of p38MAPK cascade
positive regulation of telomere capping
activation of MAPK activity
protein phosphorylation
phosphorylation
determination of dorsal identity
