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产品信息
H00005603-M02
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D8
抗原
MAPK13 (AAH00433, 251 a.a. approximately 365 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDRRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL
靶标信息
MAPK13 (p38 delta) is a serine/threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP kinase 13; MAP kinase p38 delta; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4
基因别名: MAPK 13; MAPK-13; MAPK13; p38delta; PRKM13; SAPK4
UniProt ID: (Human) O15264
Entrez Gene ID: (Human) 5603
MAPK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
response to stress
response to osmotic stress
cell cycle
peptidyl-serine phosphorylation
positive regulation of interleukin-6 production
intracellular signal transduction
vascular endothelial growth factor receptor signaling pathway
positive regulation of inflammatory response
