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产品信息
H00007867-M02
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2B5
抗原
MAPKAPK3 (AAH01662, 272 a.a. approximately 382 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: EVSEDAKQLI RLLLKTDPTE RLTITQFMNH PWINQSMVVP QTPLHTARVL QEDKDHWDEV KEEMTSALAT MRVDYDQVKI KDLKTSNNRL LNKRRKKQAG SSSASQGCNN Q
靶标信息
MAPKAPK3 functions as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. MAPKAPK3 was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. MAPKAPK3 was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3pK; Chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAPK-3; mitogen activated protein kinase-activated protein kinase 3; OTTHUMP00000210806; OTTHUMP00000210807
基因别名: 3PK; AI874665; MAPKAP-K3; MAPKAP3; MAPKAPK-3; MAPKAPK3; MapkKapk3; MK-3; MK3
UniProt ID: (Human) Q16644, (Mouse) Q3UMW7
Entrez Gene ID: (Human) 7867, (Mouse) 102626
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
MAP kinase kinase activity
protein binding
calmodulin binding
ATP binding
calcium-dependent protein serine/threonine kinase activity
nucleotide binding
protein kinase activity
signal transducer activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase binding
non-receptor serine/threonine protein kinase
MAPK cascade
activation of MAPK activity
toll-like receptor signaling pathway
response to stress
signal transduction
cell surface receptor signaling pathway
Ras protein signal transduction
peptidyl-serine phosphorylation
response to lipopolysaccharide
response to cytokine
macropinocytosis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
protein phosphorylation
phosphorylation
