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产品信息
MA1-40315
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human
宿主/亚型
Mouse
/ IgG3
分类
Monoclonal
类型
Antibody
克隆号
PLK-1
抗原
Human alveolar macrophages (recognizes domain V between residues 420 and 431)
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 0.1% BSA
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2140582
产品详细信息
Endotoxin: 0.40 EU/mg
Application Notes: IHC (frozen) - tissue sections can be fixed in acetone or 2% paraformaldehyde. Western blot - use non-reducing conditions. Flow - this antibody weakly stains alveolar macrophages by recognizing the extracellular domain of MARCO, with transfected COS cells used as a positive control. Immunoprecipitation - will immunoprecipitate MARCO as a 60 kDa and 50 kDa protein from transfected COS lysates. Functional Assays - blocks human alveolar macrophages by recognizing the extracellular doamin of MARCO.
Recommended positive control: Human alveolar macrophages; Negative control: All other human cells.
靶标信息
MARCO, also known as SR-A6 or SCARA2, is a macrophage surface receptor and a member of the class A scavenger receptor family. As a part of the innate antimicrobial immune system, MARCO can bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. Due to its expression in tumor infiltrating macrophages, and its role in inhibiting immune responses within tumor environment, MARCO has been indicated as a potential target for cancer immunotherapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Macrophage receptor MARCO; Macrophage receptor with collagenous structure; Scavenger receptor class A member 2; scavenger receptor class A, member 2; SR-A6
基因别名: MARCO; SCARA2
UniProt ID: (Human) Q9UEW3
Entrez Gene ID: (Human) 8685
