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MARK1 Antibody (PA5-29402) in WB
Western Blot using MARK1 Polyclonal Antibody (Product # PA5-29402). Sample (30 µg of whole cell lysate). Lane A: A431. 7.5% SDS PAGE. MARK1 Polyclonal Antibody (Product # PA5-29402) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
PA5-29402
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 1 and 265 of Human MARK1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2546878
产品详细信息
Recommended positive controls: A431, H1299, HeLa.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (94%), Xenopus laevis (96%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP/microtubule affinity-regulating kinase 1; MARK1; Par-1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1
基因别名: KIAA1477; MARK; MARK1; Par-1c; Par1c
UniProt ID: (Human) Q9P0L2
Entrez Gene ID: (Human) 4139
