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产品信息
TA590402
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
偶联物
形式
Liquid
浓度
0.86277 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.
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生物信息学
蛋白别名: MARVEL (membrane-associating) domain containing 2; MARVEL domain-containing protein 2; Tricellulin
基因别名: DFNB49; MARVD2; MARVELD2; MRVLDC2; TRIC
UniProt ID: (Human) Q8N4S9
Entrez Gene ID: (Human) 153562
