Invitrogen

MCP-1 Polyclonal Antibody

MCP-1 Antibody in Immunohistochemistry (IHC)

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MCP-1 Antibody (PA5-34505) in IHC

Immunohistochemistry of CCL2 in human spleen tissue with MCP-1 Polyclonal Antibody (Product # PA5-34505) at 5 µg/mL.

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产品信息

PA5-34505

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化 (IHC)

5 µg/mL

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免疫组化（石蜡） (IHC (P))

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A 17 amino acid peptide near the carboxy terminus of human CCL2

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2551857

产品详细信息

A suggested positive control is rat spleen tissue lysate.

PA5-34505 can be used with blocking peptide PEP-1548.

靶标信息

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Oxidative medicine and cellular longevity

Zhao T,Kee HJ,Kee SJ,Jeong MH

Published figure using MCP-1 polyclonal antibody (Product # PA5-34505) in Western Blot

Wed Mar 09 00:00:00 EST 2022

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.

iScience

Fu H,Gui Y,Liu S,Wang Y,Bastacky SI,Qiao Y,Zhang R,Bonin C,Hargis G,Yu Y,Kreutzer DL,Biswas PS,Zhou Y,Wang Y,Tian XJ,Liu Y,Zhou D

PA5-34505 was used in Western Blot, Immunohistochemistry (Paraffin) to validate that loss of c-met influences epithelial plasticity, myofibroblast activation, and extracellular matrix synthesis/degradation, which ultimately determined the characteristics of the fibrotic KLM.

Fri Oct 22 00:00:00 EDT 2021

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment.

iScience

Fu H,Gui Y,Liu S,Wang Y,Bastacky SI,Qiao Y,Zhang R,Bonin C,Hargis G,Yu Y,Kreutzer DL,Biswas PS,Zhou Y,Wang Y,Tian XJ,Liu Y,Zhou D

Fri Oct 22 00:00:00 EDT 2021

Pre-eclamptic Fetal Programming Alters Neuroinflammatory and Cardiovascular Consequences of Endotoxemia in Sex-Specific Manners.

The Journal of pharmacology and experimental therapeutics

Abuiessa SA,Wedn AM,El-Gowilly SM,Helmy MM,El-Mas MM

PA5-34505 was used in Immunohistochemistry to suggest a sexual dimorphism in the interaction of pre-eclamptic fetal programming with endotoxemia.

Fri May 01 00:00:00 EDT 2020

Use of magnetic capture to identify elevated levels of CCL2 following intra-articular injection of monoiodoacetate in rats.

Connective tissue research

Yarmola EG,Shah YY,Lakes EH,Pacheco YC,Xie DF,Dobson J,Allen KD

PA5-34505 was used in Immunohistochemistry to study magnetic capture of CCL2 to determine levels of CCL2 in a rat knee. Magnetic capture detected a statistically significant increase of CCL2 in monoiodoacetate (MIA) injected knees compared to controls, and CCL2 levels stayed relatively stable from week 1 through week 4 post-MIA injection.

Tue Sep 01 00:00:00 EDT 2020

生物信息学

蛋白别名: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; H-MCP-1; HC11; immediate-early serum-responsive JE protein; Immediate-early serum-responsive protein JE; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; Small-inducible cytokine A2

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基因别名: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF

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UniProt ID: (Human) P13500, (Rat) P14844, (Mouse) P10148

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Entrez Gene ID: (Human) 6347, (Rat) 24770, (Mouse) 20296

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功能

protein kinase activity receptor binding chemokine activity heparin binding CCR2 chemokine receptor binding G-protein coupled receptor binding cytokine activity protein binding cytokine intercellular signal molecule

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