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MCT2 Antibody (PA5-120845) in WB
Western blot analysis of MCT2 in extracts of various cell lines. Samples were incubated with MCT2 Polyclonal antibody (Product # PA5-120845) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-120845
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 379-478 of human SLC16A7 (NP_0012575511)
偶联物
Unconjugated
形式
Liquid
浓度
0.34 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2914417
产品详细信息
Positive test controls include: DU145, HepG2, HL-60, 293T, rat brain. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: TIVECGPVLL GPPLAGKLVD LTGEYKYMYM SCGAIVVAAS VWLLIGNAIN YRLLAKERKE ENARQKTRES EPLSKSKHSE DVNVKVSNAQ SVTSERETNI
靶标信息
Tissues with few or no mitochondria, such as erythrocytes and tumor cells, depend largely on glycolysis to generate ATP. The major end products of glycolysis, pyruvate and lactate, must be eliminated from these cells to enable continued glycolytic flux and prevent toxic effects. H+/monocarboxylate transporters mediate the transport of lactate and pyruvate. Human MCT2 has a high affinity for the transport of pyruvate.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MCT 2; monocarboxylate transporter; Monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; Solute carrier family 16 member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
基因别名: MCT2; SLC16A7
UniProt ID: (Human) O60669, (Rat) Q63344
Entrez Gene ID: (Human) 9194, (Rat) 29735
pyruvate secondary active transmembrane transporter activity
monocarboxylic acid transmembrane transporter activity
lactate transmembrane transporter activity
symporter activity
pyruvate transmembrane transporter activity
protein binding
secondary active monocarboxylate transmembrane transporter activity
transporter
