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MCU Antibody (MA5-24702) in ICC/IF
Immunofluorescent staining of MCU in human A549 cells using the MCU monoclonal antibody (Product # MA5-24702), showing specific staining in the mitochondria in green. Microtubule- and nuclear probes are visualized in red and blue, respectively (where available).
产品信息
MA5-24702
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
CL3576
抗原
Recombinant Human MCU
偶联物
Unconjugated
形式
Liquid
浓度
1.00 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2664126
产品详细信息
Immunogen sequence: TRQEYVYPEAR DRQYLLFFHK GAKKSRFDLE KYNQLKDAIA QAEMDLKRLR DPLQVHLPLR QIGE
Binds to an epitope located within the peptide sequence RDRQYLLFFH as determined by overlapping synthetic peptides.
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
靶标信息
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Calcium uniporter protein, mitochondrial; Coiled-coil domain-containing protein 109A; HsMCU
基因别名: C10orf42; CCDC109A; MCU
UniProt ID: (Human) Q8NE86
Entrez Gene ID: (Human) 90550
