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ME1 encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cytosolic malic enzyme 1; malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Malic enzyme 1; malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; malic enzyme, supernatant; NADP-dependent malic enzyme; NADP-ME; pyruvic-malic carboxylase
基因别名: D9Ertd267e; HUMNDME; Mdh-1; ME1; MES; Mod-1; MOD1
UniProt ID: (Human) P48163, (Mouse) P06801
Entrez Gene ID: (Human) 4199, (Mouse) 17436, (Rat) 24552