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产品信息
17340-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
MEK4 Fusion Protein Ag11376 (50-399 aa encoded by BC036032)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NPPFKSTAR FTLNPNPTGV QNPHIERLRT HSIESSGKLK ISPEQHWDFT AEDLKDLGEI GRGAYGSVNK MVHKPSGQIM AVKRIRSTVD EKEQKQLLMD LDVVMRSSDC PYIVQFYGAL FREGDCWICM ELMSTSFDKF YKYVYSVLDD VIPEEILGKI TLATVKALNH LKENLKIIHR DIKPSNILLD RSGNIKLCDF GISGQLVDSI AKTRDAGCRP YMAPERIDPS ASRQGYDVRS DVWSLGITLY ELATGRFPYP KWNSVFDQLT QVVKGDPPQL SNSEEREFSP SFINFVNLCL TKDESKRPKY KELLKHPFIL MYEERAVEVA CYVCKILDQM PATPSSPMYV D (50-399 aa encoded by BC036032)
靶标信息
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-JUN N-terminal kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 4; JNK kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; JNKK; JNKK 1; MAP kinase kinase 4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; mitogen activated protein kinase kinase 4, variant 1; SAPK kinase 1; SAPK/ERK kinase 1; SAPK/Erk/kinase 1; SEK1; Stress-activated protein kinase kinase 1
基因别名: JNKK; JNKK1; MAP2K4; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985, (Mouse) P47809
Entrez Gene ID: (Human) 6416, (Mouse) 26398
protein kinase activity
receptor signaling protein serine/threonine kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
nucleotide binding
protein serine/threonine kinase activity
MAP kinase kinase activity
JUN kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
mitogen-activated protein kinase kinase kinase binding
non-receptor serine/threonine protein kinase
apoptotic process
signal transduction
JNK cascade
response to wounding
peptidyl-tyrosine phosphorylation
proteolysis in other organism
Fc-epsilon receptor signaling pathway
cellular response to mechanical stimulus
negative regulation of motor neuron apoptotic process
MAPK cascade
positive regulation of protein phosphorylation
protein phosphorylation
activation of JUN kinase activity
phosphorylation
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
positive regulation of DNA replication
positive regulation of nitric-oxide synthase biosynthetic process
cell growth involved in cardiac muscle cell development
