Invitrogen

MEK5 Monoclonal Antibody (2C2)

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MEK5 Antibody in Immunocytochemistry (ICC/IF)

MEK5 Antibody in Immunocytochemistry (ICC/IF)

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MEK5 Antibody (MA5-19712) in ICC/IF

Immunofluorescence analysis of HeLa cells using an anti-MAP2K5 monoclonal antibody (Product # MA5-19712). (antibody concentration 10 µg/mL).

MEK5 Antibody in Immunocytochemistry (ICC/IF)

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MEK5 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescence analysis of HeLa cells using an anti-MAP2K5 monoclonal antibody (Product # MA5-19712). (antibody concentration 10 µg/mL).

产品信息

MA5-19712

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫细胞化学 (ICC/IF)

10 µg/mL

-

酶联免疫吸附实验 (ELISA)

Assay-Dependent

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

2C2

抗原

MAP2K5 (AAH08838, 1 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2-1.0 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2607962

产品详细信息

Peptide Sequence: MLWLALGPFP AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL

靶标信息

MAP2K5 (MEK5) serine/threonine kinase (mitogen-activated protein kinase 5) or MEK5 is a dual specificity protein kinase that belongs to the MAP kinase family which specifically interacts with and activates MAPK7/ERK5. MAP2K5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MAP2K5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect the risk of developing colorectal cancer (CRC).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MEK 5

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基因别名: HsT17454; MAP2K5; MAPKK5; MEK5; MKK5; PRKMK5

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UniProt ID: (Human) Q92962

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Entrez Gene ID: (Human) 5607

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protein kinase activity receptor signaling protein serine/threonine kinase activity protein tyrosine kinase activity protein binding ATP binding metal ion binding non-receptor serine/threonine protein kinase

参与通路

negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity signal transduction heart development peptidyl-tyrosine phosphorylation positive regulation of cell growth negative regulation of NF-kappaB transcription factor activity negative regulation of heterotypic cell-cell adhesion negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of interleukin-8 biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of epithelial cell proliferation positive regulation of protein metabolic process negative regulation of response to cytokine stimulus ERK5 cascade cellular response to growth factor stimulus cellular response to laminar fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis negative regulation of chemokine (C-X-C motif) ligand 2 production negative regulation of extrinsic apoptotic signaling pathway in absence of ligand