Invitrogen

MFN2 Polyclonal Antibody

MFN2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MFN2 Antibody (PA5-72811) in IHC (P)

Immunofluorescence of MFN2 in mouse brain tissue with MFN2 Polyclonal Antibody (Product # PA5-72811) at 20 µg/mL. Green: MFN2 Red: Phylloidin staining Blue: DAPI staining

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产品信息

PA5-72811

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-2 µg/mL

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免疫组化（石蜡） (IHC (P))

5 µg/mL

酶联免疫吸附实验 (ELISA)

Assay-Dependent

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

MFN2 antibody for a 17 amino acid peptide near the center of human MFN2. The immunogen is within amino acids 250 - 300 of MFN2.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2718665

靶标信息

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma.

Cells

Bertola N,Degan P,Cappelli E,Ravera S

PA5-72811 was used in Western Blotting to evaluate the effect of FANCA mutation on the energy metabolism and the relative mitochondrial quality control pathways in an head and neck squamous cell carcinoma cellular model.

Sat Jul 30 00:00:00 UTC 2022

Mutated FANCA Gene Role in the Modulation of Energy Metabolism and Mitochondrial Dynamics in Head and Neck Squamous Cell Carcinoma.

Cells

Bertola N,Degan P,Cappelli E,Ravera S

Sat Jul 30 00:00:00 UTC 2022

Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells.

Antioxidants (Basel, Switzerland)

Marini C,Cossu V,Carta S,Greotti E,Gaglio D,Bertola N,Chiesa S,Bruno S,Vitale F,Bonanomi M,Porro D,Riondato M,Orengo AM,Bauckneht M,Morbelli S,Ravera S,Sambuceti G

Published figure using MFN2 polyclonal antibody (Product # PA5-72811) in Western Blot

Mon Dec 26 00:00:00 UTC 2022

The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1^G93A Mouse Model of Amyotrophic Lateral Sclerosis.

Antioxidants (Basel, Switzerland)

Marini C,Cossu V,Kumar M,Milanese M,Cortese K,Bruno S,Bellese G,Carta S,Zerbo RA,Torazza C,Bauckneht M,Venturi C,Raffa S,Orengo AM,Donegani MI,Chiola S,Ravera S,Castellani P,Morbelli S,Sambuceti G,Bonanno G

Published figure using MFN2 polyclonal antibody (Product # PA5-72811) in Western Blot

Mon Aug 30 00:00:00 UTC 2021

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.

EJNMMI research

Marini C,Cossu V,Bonifacino T,Bauckneht M,Torazza C,Bruno S,Castellani P,Ravera S,Milanese M,Venturi C,Carlone S,Piccioli P,Emionite L,Morbelli S,Orengo AM,Donegani MI,Miceli A,Raffa S,Marra S,Signori A,Cortese K,Grillo F,Fiocca R,Bonanno G,Sambuceti G

PA5-72811 was used in Western Blotting to assess whether enhanced [18F]-fluorodeoxyglucose (FDG) uptake predictive potential reflects the link between [18F]-fluorodeoxyglucose uptake and redox stress that has been previously reported in different tissues and disease models.

Tue Jul 07 00:00:00 UTC 2020

Mechanisms underlying the predictive power of high skeletal muscle uptake of FDG in amyotrophic lateral sclerosis.

EJNMMI research

Tue Jul 07 00:00:00 UTC 2020

生物信息学

蛋白别名: CPRP 1; HSG protein; hyperplasia suppressor; hypertension related protein 1; hypertension-related protein; Hypertension-related protein 1; MFN 2; Mitochondrial assembly regulatory factor; mitochondrial transmembrane GTPase FZO1A; Mitofusin-2; Mitofusin2; Transmembrane GTPase MFN2

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基因别名: CMT2A; CMT2A2; CPRP1; D630023P19Rik; Fzo; HMSN6A; HSG; KIAA0214; MARF; MFN2

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UniProt ID: (Human) O95140, (Mouse) Q80U63

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Entrez Gene ID: (Human) 9927, (Mouse) 170731, (Rat) 64476

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功能

GTPase activity protein binding GTP binding ubiquitin protein ligase binding nucleotide binding hydrolase activity GTPase binding

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