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产品信息
BS-24479R-HRP
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from mouse MGMT (1-100).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 0-6-methylguanine-DNA methyltransferase; 6-O-methylguanine-DNA methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; MGMT; O(6)-alkylguanine-DNA alkyltransferase; O-6-alkylguanine-DNA alkyltransferase; O-6-methylguan; O-6-methylguanine-DNA-alkyltransferase; O6-alkylguanine-DNA alkyltransferase; O6-methylguanine-DNA methyltranferase
基因别名: Agat; AGT; AI267024; Mgmt
UniProt ID: (Rat) P24528, (Mouse) P26187
Entrez Gene ID: (Rat) 25332, (Mouse) 17314
DNA repair
DNA dealkylation involved in DNA repair
cellular response to DNA damage stimulus
response to toxic substance
response to organic cyclic compound
methylation
cellular response to oxidative stress
response to drug
regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to ethanol
positive regulation of DNA repair
response to folic acid
negative regulation of cell death
mammary gland epithelial cell differentiation
cellular response to organic cyclic compound
cellular response to ionizing radiation
