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Antibody detects endogenous levels of total MIA3.
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES (PubMed:28442536). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: C219-reactive peptide; D320; melanoma inhibitory activity family member 3; melanoma inhibitory activity family, member 3; Melanoma inhibitory activity protein 3; RP11-378J18.4; TANGO1; transport and Golgi organization protein 1; Transport and Golgi organization protein 1 homolog
基因别名: 9130229H14Rik; A930039G15Rik; ARNT; AU022327; B230399H06Rik; C80126; D320; Gm1525; KIAA0268; MIA3; TANGO; TANGO1; UNQ6077; UNQ6077/PRO20088
UniProt ID: (Human) Q5JRA6, (Mouse) Q8BI84
Entrez Gene ID: (Human) 375056, (Mouse) 338366, (Rat) 683007
分子生物学功能:
membrane traffic protein