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MICA Antibody (TA813288) in WB
Western blot analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Cat # PS100001, Left lane) or pCMV6-ENTRY MICA/MICB (Cat # RC204447]/Cat # RC222315 Middle/, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and blotted with anti-MICA antibody (Cat # TA813288)(1:1000).
产品信息
TA813288
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2F5
抗原
Full length human recombinant protein of human MICA (NP_000238) produced in HEK293T cell.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with 50% glycerol, 1% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Dilute in PBS (pH7.3) if necessary. Stable for 12 months from date of receipt.
靶标信息
Major histocompatibility complex (MHC) class I proteins are ubiquitously expressed and mediate the recognition of intracellular antigens by cytotoxic T cells. A related family, termed the MHC class I chain-related (MIC) proteins are recognized by NKG2D, a receptor on NK and T cells, and promote anti-tumor activity. MICA, a member of the MIC family, is widely expressed on many tumors, and it is the MICA/NKG2D interaction that is thought to stimulate the anti-tumor reactivity by T lymphocytes. Both MICA and MICB mRNA are widely expressed in normal tissues, with MICA being present in virtually every tissue except the nervous system, suggesting that MIC protein expression may only be one component of the anti-tumor activity of the immune system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAMA-345G11.2; HLA class I antigen; MHC class I chain-related protein A; MHC class I polypeptide-related sequence A; MHC class I related sequence A; MIC-A; MICA; stress inducible class I homolog; truncated MHC class I polypeptide-related sequence A
基因别名: MIC-A; MICA; PERB11.1
UniProt ID: (Human) Q9TQA4
Entrez Gene ID: (Human) 100507436
T cell mediated cytotoxicity
immune response to tumor cell
cellular response to DNA damage stimulus
response to heat
cytolysis
antigen processing and presentation
negative regulation of natural killer cell activation
natural killer cell mediated cytotoxicity
defense response to bacterium
negative regulation of natural killer cell mediated cytotoxicity
gamma-delta T cell activation
regulation of immune response
defense response to virus
