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Immunogen sequence: IRRSLEPLLS NSEGGKKAWA KQESKTLPTQ ACTRSFSLRK TNSNKDGDQH SPGRNQSSAF SPPDPALRTH SLPNRPSKVF PALRSPPCSK IEDVPTLL
Highest antigen sequence identity to the following orthologs: Mouse - 49%, Rat - 50%.
MICALs (Molecules Interacting with CasL) are atypical multidomain flavoenzymes with diverse cellular functions. There are three known isoforms, MICAL1, MICAL2 and MICAL3, as well as the MICAL-like proteins MICAL-L1 and MICAL-L2. MICAL2 has three conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain and a Lin11, Isl-1 and Mec-3 (LIM) domain. It has been demonstrated that MICAL2 could regulate actin stress fibers and is required for normal actin organization. In addition, MICAL2-PV, a novel splicing variants of MICAL2, has been reported to be involved in cancer progression of prostate cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: [F-actin]-monooxygenase MICAL2; flavoprotein oxidoreductase MICAL2; MICAL C-terminal-like protein; MICAL-2; Mical-cL; microtubule associated monoxygenase, calponin and LIM domain containing 2; Molecule interacting with CasL protein 2
基因别名: KIAA0750; MICAL-2; MICAL2; MICAL2PV1; MICAL2PV2; MICALCL
UniProt ID: (Human) O94851
Entrez Gene ID: (Human) 9645