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产品信息
MA5-30675
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
103
抗原
Recombinant Human MICB protein (Met1-Gly298)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2786370
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human MICB/MIC-B.
靶标信息
MICB encodes the highly polymorphic MHC (HLA) class I chain-related gene B. The protein product is expressed on the cell surface. It is thought that MICB functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. MICB is broadly recognized by NK cells and T cells with NKG2D receptor on their surface. The complex NKG2D-MICB results in MICB expressing cytolytic T cells and NK cells against epithelial tumor cells.
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生物信息学
蛋白别名: MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I polypeptide-related sequence B; MHC class I-like molecule PERB11.2-IMX; MIC-B; MICB; sMICB; soluble MICB; stress inducible class I homolog
基因别名: MICB; PERB11.2
UniProt ID: (Human) Q29980
Entrez Gene ID: (Human) 4277
T cell mediated cytotoxicity
immune response-activating cell surface receptor signaling pathway
response to oxidative stress
response to heat
viral process
cytolysis
antigen processing and presentation
response to retinoic acid
natural killer cell mediated cytotoxicity
gamma-delta T cell activation
negative regulation of defense response to virus by host
regulation of immune response
