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产品信息
PA5-109957
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 478-667 of human MID1 (NP_000372.1).
偶联物
形式
Liquid
浓度
0.54 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2855368
产品详细信息
Immunogen sequence: KLKTNSQPFK LDPKSAHRKL KVSHDNLTVE RDESSSKKSH TPERFTSQGS YGVAGNVFID SGRHYWEVVI SGSTWYAIGL AYKSAPKHEW IGKNSASWAL CRCNNNWVVR HNSKEIPIEP APHLRRVGIL LDYDNGSIAF YDALNSIHLY TFDVAFAQPV CPTFTVWNKC LTIITGLPIP DHLDCTEQLP
靶标信息
Midline-1 (Tripartite motif-containing protein 18, Putative transcription factor XPRF, RING finger protein 59) is a 667 amino acid protein encoded by the human gene MID1. Midline-1 belongs to the TRIM/RBCC family and contains two B box-type zinc fingers, one B30.2/SPRY domain, one COS domain, one fibronectin type-III domain and one RING-type zinc finger. Midline-1 is believed to have E3 ubiquitin ligase activity which targets the catalytic subunit of protein phosphatase 2 for degradation. It is a cytoplasmic protein found as a homodimer or heterodimer with Midline-2. It also interacts with IGBP1 (Lymphocyte signaling protein A4). Defects in MID1 are the cause of Opitz syndrome type I (OS-I). OS-I is an X-linked recessive disorder characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase Midline-1; Midin; midline 1 RING finger protein; Opitz/BBB syndrome; Putative transcription factor XPRF; RING finger protein 59; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; tripartite motif protein TRIM18; Tripartite motif-containing protein 18; zinc finger on X and Y, mouse, homolog of
基因别名: 61B3-R; BBBG1; DXHXS1141; FXY; GBBB1; MID1; MIDIN; OGS1; OS; OSX; RNF59; TRIM18; XPRF; ZNFXY
UniProt ID: (Human) O15344, (Mouse) O70583
Entrez Gene ID: (Human) 4281, (Mouse) 17318
protein binding
microtubule binding
zinc ion binding
ligase activity
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
protein heterodimerization activity
phosphoprotein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
