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Immunogen sequence: SADMLVHDF DDERTLEEEE MMEGETNFSS EIEDLAREGD MPIHELLSLY GYGSTVRLPE EDEEEEEEEE EGEDDEDADN DDNSGCSGEN KEENIKDSSG QEDETQSSND DPSQSVASQD AQEIIRPRRC KYFDTNSEVE EESEEDEDYI PSEDWKKEIM VGSMFQAEIP VGICRY (49-224 aa encoded by BC017423)
The association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters. Results demonstrate that alternate use of a facultative intron regulates the subcellular localization of hMI-ER1 proteins and this may have important implications for hMI-ER1 function in the regulation of transcription. Repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Early response 1; hMI-ER1; mesoderm induction early response 1 homolog; mesoderm induction early response 1, transcriptional regulator; Mesoderm induction early response protein 1; RP5-944N15.1
基因别名: 4933425I22Rik; 5830411K19Rik; ER1; KIAA1610; MI-ER1; MIER1; RGD1562337
UniProt ID: (Human) Q8N108, (Mouse) Q5UAK0
Entrez Gene ID: (Human) 57708, (Mouse) 71148, (Rat) 313418
分子生物学功能:
homeodomain transcription factor